NIH requires adding PMCID to references cited in proposals, and PMCID may be difficult to add because many reference libraries and citation styles omit them. As a result, some colleagues add them manually, which is rather time consuming. To avoid this drudgery, I wrote a couple of scripts available from this GitHub repository that allow … Continue reading Bibliography for NIH proposals
The cost of omics
Next generation DNA sequencing is ubiquitously integrated in modern biomedical research while mass-spectrometry proteomics remains less ubiquitous. In fact, mass-spectrometry proteomics is conspicuously missing from projects that desperately need it. Why is DNA sequencing better integrated with biomedical research? This question comes up often in my conversations with colleagues. A commonly suggested answer is the … Continue reading The cost of omics
We -- the research community -- can be much more successful if we invest more time and effort in what matters: Coming up with original new leads and helping each other grow as scientists and people. Happy and successful year to everybody!
The bigger picture
Publishing a paper in a top journal may be relatively unimportant.
When do you need single-cell analysis?
At HUPO, I have been repeatedly asked: "Why analyze single cells when you can identify more peptides in bulk samples?"
Direct causal mechanisms
Understanding biological systems: In search of direct causal mechanisms The advent of DNA-microarrays spurred a vigorous effort to reverse engineer biological networks. Recently, these efforts have been reinvigorated by the availability of RNA-seq data from perturbed and unperturbed single cells. In the talk below, I discuss the opportunities and limitations of using such data for … Continue reading Direct causal mechanisms
I am hugely enthusiastic for communicating research by preprints. So naturally, I am happy to see when the president and strategic advisers of one of the most elite funding institutes embraces preprints: https://twitter.com/slavovLab/status/1095734247384641541 For centuries, publishing a scientific article was just about sharing the results. More recently, publishing research articles in a journal has served … Continue reading Evaluating preprints
The success of imaging technologies The molecular and functional differences among the cells making our bodies have been appreciated for many decades. Yet, the tools to study them were very limited. In the last couple of decades, we have began developing increasingly powerful technologies for molecular single-cell measurements. Currently, the most widely used high-throughput methods … Continue reading Single-cell analysis
I am sorry for not referencing your paper, but it would have undermined the novelty of our work. You know how Nature editors think.
Why I love preprints
The most frequent argument revolves around fear of losing priority of discovery. My usual question is: Have you ever felt that one of your peer reviewed papers is not cited and given credit when it should have been?