I cannot read it and agree with claims that peer review “is broken” and does not work. Such claims are at best oversimplifying the problems and selectively excluding evidence.
Direct causal mechanisms
Understanding biological systems: In search of direct causal mechanisms The advent of DNA-microarrays spurred a vigorous effort to reverse engineer biological networks. Recently, these efforts have been reinvigorated by the availability of RNA-seq data from perturbed and unperturbed single cells. In the talk below, I discuss the opportunities and limitations of using such data for … Continue reading Direct causal mechanisms
Ever since my lab posted the SCoPE-MS preprint, I have been repeatedly asked about the future potential and the cost of quantifying proteins by high-throughput mass-spectrometry in single cells. I will summarize a few thoughts that hopefully will be helpful and will reduce email traffic. Why quantify proteins and PTMs in single cells? Single-cell RNA-seq … Continue reading Single-cell proteomics